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KMID : 0359920110300050523
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Korean Journal of Nephrology
2011 Volume.30 No. 5 p.523 ~ p.527
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Renal Infarction Concurrent with Multiple Venous Thrombosis in Association with Inherited Antithrombin Deficiency
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Ko Sun-Hye
Lee Hong-Seok
Jang Ji-Hye
Kim Ji-Hyun
Yoon Hye-Eun
Chung Hyun-Hwa
Shin Seok-Joon
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Abstract
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Antithrombin deficiency is a rare condition among the numerous conditions that can lead to a hypercoagulable state, and can manifest as deep vein thrombosis, portal or mesenteric venous thrombosis, pulmonary thromboembolism and cerebrovascular accidents. In this report, we present a case of acute renal infarction and multiple venous thrombosis in a 36-year-old man with a family history of thromboembolism. He presented with a sudden onset of pain in the right flank and was admitted to the emergency room for evaluation. On computed tomography and renal angiography, the diagnosis of acute renal infarction concurrent with portal, splenic and superior mesenteric venous thrombosis was made. Laboratory data revealed parallel decreases in activity and antigen concentration of antithrombin despite normal liver and renal functions. He was treated with intravenous heparin and fresh frozen plasma followed by concomitant warfarin therapy. Taken together, the etiology of acute renal infarction and multiple venous thrombosis was considered to be associated with type I inherited antithrombin deficiency.
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KEYWORD
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Antithrombin III deficiency, Kidney, Infarction, Thrombosis, Anticoagulant
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